TY  - JOUR
AU  - ADMACHE, PREMLATA
AU  - MISHRA, ASHWANI
TI  - FORMULATION AND EVALUATION OF CAPSULE CONTAINING ESOMEPRAZOLE GRANULE FOR THE  TREATMENT OF GASTRIC ULCER
JF  - International Journal on Current Trends in Drug Development & Industrial Pharmacy [ISSN: 2581-7655 (online)]; Vol 1 No 1 (2017): International Journal on Current Trends in Drug Development & Industrial Pharmacy
KW  - 
N2  -  Proton pump inhibitors (PPIs) are most widely prescribed classes of medications in the primary care treatment of acid-peptic diseases. Esomeprazole is a unique and potent agent for suppression of gastric acid secretion and that’s how it mitigate the problem of Ulcer. In this study an attempt was made to formulate granules of Esomeprazole using wet granulation method and then finally they were entrapped in to the Capsule. Two types of granules were prepared immediate release granules and Controlled release granules by using different polymers, For Immediate release granules were prepared by using gas generating agent by sodium bi carbonate, polyvinyl pyrollidon, carboxy methyl cellulose and isopropyl alcohol as a wetting agent. and for sustained release granules hydroxyl propyl methyl cellulose, carboxy methyl cellulose were used. The purpose was to improve the of formulation bioavailability. Prepared granules were evaluated for bulk density, Tapped density, percent compressibility, Hausners ration and prepared formulation were evaluated for entrapment efficiency and In vitro drug release. The maximum drug release was found to be 45% at 180 minutes. 
UR  - http://medical.eurekajournals.com/index.php/IJCTDDIP/article/view?path=