FORMULATION AND IN VITRO EVALUATION OF BILAYER TABLETS OF ANTIDIABETIC DRUG REPAGLINIDE

Abstract

Layered formulations have commenced new way of formulating formulations. These are used for same drug to modify its release and for different drug with the ration of using both the drug in to the same formulation. The most common layered formulation is multilayer tablet, They are used in the Pharmaceutical formulation due to their number of Advantages. In this research work an antidiabetic drug repaglinide is used for the preparation of the bilayer tablet, Two layers of the drug were formulated one for the immediate release of the drug and other one is for the sustained release of the drug, Then these prepared formulation having different amount polymer were subjected for the evaluation parameters like weight variation, thickness, hardness, friability and then in vitro drug release. Out of three different batched in which concentration of super disintegrants sodium starch Glycolate and polymer HPMC adjusted and best formulation was selected on the basis of the evaluation performed.