Prediction Analysis of Pharmacokinetic, Toxicological and Druglikeliness Parameters of Several oral Hypoglycemic Agents of Sulfonyl Ureas Second Generation using in-Silico Methods

Abstract

Sulfonylureas are widely used in treatment of Diabetes as a hypoglycemic agent due to its safe and effective use. In this research work an Effort is made to analyze the second generation Sulfonylureas on the basis of insilico toxicity study, ADME sar study and Drug likeliness properties. The four drugs which used in this insilico research work are glibenclamide, gliclazide, glipizide, and glimepiride.In this study it has been observed that all the drugs were within the bioavailabily radar. The best skin permeability score was exhibited by glimepiride and Highest gastrointestinal absorption. glibenclamide revealed violation of Lipinski rule of 5 as compared to other three drugs. In the case of in-silico toxicity study some sign of liver toxicity has been observed with Glebenclamide. On the basis of Physiochemical properties, druglikeliness study and skin permeability study Glimepiride proved its better therapeutic profile as compared to other three drugs in the study.