In Silico Screening of Different Natural Dyeing agent on the Basis of their Efficiency to Stain and Sensitivity to Human Skin

Abstract

Staining agents or dyes have been widely used in the cosmetic products, and since many years natural dyeing agents has been majorly used in the cosmetic industry. They have been in major use due to their compatibility with the skin and safety profile. In some study it has been observed that even if the product is of natural origin they do have different undesirable effect or side effect. In this research work skin sensitivity of natural dyeing agent was analyzed, Adsorption, distribution, metabolism, excretion and toxicity properties were also analyzed and skin permeability properties were analyzed. All these analysis were done of natural dyeing agents were also studied For this study five natural dyeing agents were chosen Curcumine, Lawsone, Betanin, Juglone and Indigo. An attempt was also made to perform ADME toxicity, skin se so that the gastrointestinal system based compatibility of these agents can be checked and analyzed. The result of these studies exhibited that Betanin and Curcumine are the best and safe coloring agents that can be used in cosmetic industry as per in-silico potential determining study of this research work.