IN-SITU NASAL GEL A PANACEA FORMULATION FOR NASAL DRUG DELIVERY

Abstract

In-situ Nasal gel are novel formulation intended to provide desired pharmacological effect on specific site and on predetermined rate which make this pharmaceutical formulation a good formulation .Nasal route is also more permeable to compounds than gastro intestinal tract. There were many absorption mechanism were established to predict the mechanism of drug absorption from the in-situ nasal gel formulation but only two mechanism have been mostly applicable such as paracellular process and transcellular process of absorption of drug. Generally there are two methods of preparation, one is cold method and second is hot method. This in situ gel formulation can be evaluated by determining Clarity, Texture Analysis, Viscosity, drug content ,pH, gel strength, Sol-gel transition temperature and gelling time, Accelerated stability study, Interaction study, In vitro drug release studies and Ex Vivo drug release .this review shows the multi dimentional importance of in situ nasal gel .