FORMULATION AND CHARACTERIZATION OF CARBOPOL GEL CONTAINING CLOTRIMAZOLE ETHOSOMES BY MECHANICAL DISPERSION METHOD

Abstract

The purpose of the present study was to develop a Clotrimazole Ethosomes entrapped gel using soya lecithin by using mechanical-dispersion method. This was employed to enhance the bioavailability and therapeutic efficacy of the drug. Optimization of formulation was done by studying entappment efficiency of prepared batches of ethosomes. Five formulations were prepared and formulation F5 possessed good entrapment efficiency. The formulation were also valuated for size, entrapment efficiency, viscosity, morphology and zeta potential, pH, Differential scanning calorimeter and vitro permeation studies. Results of this study revealed that the Clotrimazole Ethosomes entrapped gel can be a suitable drug delivery system.