FORMULATION AND EVALUATION OF ETHOSOMAL GEL OF FLUCONAZOLE FOR TOPICAL DRUG DELIVERY

Abstract

Ethosomes has been used widely as a transdermal drug delivery system in past few years not only for improving bioavailability but also for the modified release property and compatibility as compared to the conventionally available topical formulations .In this work cold method was used to formulate Fluconazole entrapped Ethosomes for topical application .Prepared Ethosomes formulation were evaluated for Size, Percentage Entrapment, pH, Viscosity, In vitro Drug release study and interaction study .The best formulation was chosen on the basis of their release profile , entrapment efficiency and size, Then Optimized formulation RE4 and RE5 were uniformly dispersed in to the gel base of carbopol and Hydroxypropyl methyl cellulose for the proper and feasible application of the formulation on skin. These results obtained after determining Viscosity and pH of the Fluconazole ethosomes entrapped in gel were satisfactory, which confirmed that ethosomes could be efficient carrier for topical administration of fluconazole.