In Silico Screening of Bioactive Surfactant obtained from Indian Marine Sources for the Development of Pharmaceutical Formulations

Abstract

Bioactive surfactants are the best surfactants that can be used in different pharmaceutical formulations. In this work bioactive surfactant obtained from marine sources were analyzed on the basis of Physiochemical Properties, ADME properties, skin sensitivity and Drug likeliness properties of Fengycin, Surfactin, Ituridinet D, Rhamnolipid1 and Pumilacidin. Fengycin which exhibited characteristic of Ampiphilicity from Physciochemical properties calculated. Rhamnolipid 1exhibited least molecular weight 650.80 g/mol. Skin permeability score of surfactin is good as compare to all the other biosurfactants even Maximum Recommended Therapeutic Dose 213 mg/day was also revealed by the surfactin. The acceptable properties of this marine source of surfactants make Surfactin a better surfactant.