Prediction of Pharmacokinetic Parameters, Toxicological Study and Druglikeliness properties of oral hypoglycemic agents of Sulfonylfureas class-I using In-Silico Methods

Abstract

Diabetes is one of the disorder of the body in and it is spreading in higher rate in Indian due to rapid urbanization, sedentary lifestyles, unhealthy diets. Sulfonylureas a class of oral drugs of hypoglycemic agent is widely used in the treatment of this disease .In this research work and Attempt has been made to analyze the properties of first class of oral hypoglycemic agents by using insilico studies using open source online software. In in Silico Studies bioavailability, Drug likeliness property determination, Toxicological study of all the first generation oral hypoglycemic agents were done. It was observed that all the Oral hypoglycemic agents revealed good GIT absorption, Drug likeliness properties but results of insilico toxicological study reveal that only Glimepride was safe as long as the matter of liver toxicity is concerned as compared to Tolbutamide, Tolinase, Glipizide and Chlorpropamide. which Concluded that Glimepride is the best Drug of First class of Sulfonylureas class of oral hypoglycemic agents .