Cold Chain, Cold Exposure and Changing of Form of COVID-Vaccine

Abstract

COVId-19 is the hope for pandemic control. Since it is a new vaccine, there are many concerns on its efficacy and safety. The decreased efficacy of vaccine is possible if there is no good control before use in vaccination procedure. The cold chain is important in vaccine delivery and it is a forgotten determinant for vaccine efficacy in clinical practice. Appropriate temperature control is important. Sometimes, exposure to inappropriate temperature might cause change to vaccine. The change of vaccine after cold exposure is the good example.