FORMULATION AND EVALUATION OF MICROBALLONS OF FAMOTIDINE FOR THE TREATMENT OF GASTRIC ULCER

Abstract

In the present research envisaged was to prepare gastro retentive micro balloons to increase the retention time in stomach and to modulate the release pattern of drug. The formulation were prepared by solvent diffusion evaporation method in which different concentration of polymers Eudragit S 100, Hyaluronic acid were used to get the optimized formulations, These prepared formulations were subjected for further characterization were done by determining particle size, Percentage yield, percentage entrapment efficiency, surface morphology in percent buoyancy, vitro drug release. These observations suggested that floating microballoons were promising as a carrier for intragastric floating drug delivery of famotidine.