PREPARATION AND IN VITRO CHARACTERIZATION OF IN SITU OPHTHALMIC GEL OF NORFLOXACIN

Abstract

Topical anti-infectives are commonly used to treat bacterial conjunctivitis and infection of cornea caused by susceptible strains of bacteria such as S. aureus, S.epidermidis, S. pneumoniae, Enterobactercloacae. The seantiinfectives are delivered in to the eyes by the formulations like eye drops, eye ointment and other conventional formulation but since they are associated with the problems like high flushing rate, irritation and lack of retention of the formulation in to the eye A new formulation In situ gels have come which is devoid of above mention lacking and suitable for the application of anti-infective agents in ophthalmic route .In this research work in situ Gel of Norfloxacin was developed by using different grade of Hydroxy propyl methyl cellulose and Carbopol 934 .Different in situ gel formulations were prepared and evaluated for Visual Appearance and Clarity, pH, In vitro gelationstudy, Rheological studies, Drug content analysis, and in vitro drug release study. In this research work total Eight formulations were developed and after optimization of batches F8 formulation revealed, good gelling strength, clarity, acceptable pH and better in vitro drug release .This was considered as the promising in situ gel formulation of Norfloxacin.