Design, Development and Characterization of Nano-structured lipid carrier formulation Containing Olmesartan Medoxomil

Abstract

The current study was designed to explore the potential of nanostructured lipid carriers (NLCs) for oral bioavailability enhancement of Olmesartan medoxomil (OLM) by systemic design approach. OLM loaded NLCs were prepared using ultra sonic melt emulsification method. OLM-NLC was characterized by different techniques viz. differential scanning calorimetry (DSC), powder X ray diffraction (PXRD).The prepared NLCs were evaluated for their particle size and shape, polydispersity index, zeta potential and drug entrapment efficiency. The in vitro drug release profiles were evaluated using a dialysis bag with cut off 12KD. The prepared NLCs showed average sizes between 99.4 and 174 nm and polydispersity index in the range of 0.233 to 0.583. The entrapment efficiency was not very high between 51.4% to 83.4%. The scanning electron images showed almost spherical shapes with sizes lower than those obtained by light scattering. The in vitro release followed a bi-phasic pattern with an initial rapid OLM release followed by a slow release varying according to the composition. Formulation F1 showed complete drug release within the first two hours.